VOGT Guillaume


VOGT Guillaume
PhD, Genetique Humaine
Ethique Médicale et Médecine Légale-EA4569
Centre Universitaire des Saints-Pères, Faculté de médecine
45 rue des Saints-Pères., 75006 Paris
Neglected Human Genetics
Centre National de Genotypage (CNG)
2, rue Gaston Cremieux, CP-5721, 91057 Evry Cedex

I received a Ph.D. degree from the University Paris René Descartes, Necker-Enfants Malades Medical School in France, in 2006. I dedicated my doctoral work to study Mendelian predisposition to mycobacterial infections. My work opened two new avenues of research, the discovery of “gain of glycosylation” mutations and the complementation of other mutations by inhibitors of glycosylation, distinct from genetic complementation. I then worked as postdoctoral fellow in Weill Medical College of Cornell University in New York. There, I was the first to identify culture conditions of human macrophages inductive for destruction of mycobacteria. I joined the Rockefeller University in New York, as a member of the St. Giles Laboratory of Human Genetics of Infectious Diseases directed by Pr. Jean-Laurent Casanova and became a research Associate. Then, I came back in 2012 in France as Research Associate affiliated to INSERM and initiated research on genetic etiology of Whipple’s Disease.
This pioneer work opened and highlights new avenues of research in the field of human mycobacterial diseases and was a critical step in the validation of the genetic theory of infectious diseases initially proposed by the laboratory. My understanding of such a huge switch in paradigm (from ‘no infection without a microbe’ to ‘no infection without a genetic lesion’) is that the contribution of genetics to any human characteristics is major and as a rule underestimated when not just dogmatically ignored. In addition, a clear outcome of this theory is that extreme phenotypes are caused by severe genetic defects in a single gene (or pathway), while more common phenotypes are caused by the additive effects of minor lesions in a potentially large number of genes. Building on this convincing evidence that even infectious diseases long considered as purely environmental are indeed under critical genetic control of the host, I hypothesize that the vast majority of human behavioral traits are, at least in part, driven by the host genetic profile. With the work initiated with the laboratory of medical ethics and legal medicine directed by Prof. C. Hervé, I am currently working on Primary Premature Ejaculation, and Gender Dysphoria and will join as an independent team the laboratory of Dr Deleuze at the Genopole, the CEA-Centre Nationale de Génotypage.

B.Sc., University of Paris XI, Orsay, France, 09/1997-08/2000, Cellular Biology and Physiology
B.Sc., University Paris VII, Jussieu, France, 09/2000-08/2001, Genetics
M.Sc., Institut Pasteur, 28 rue du Docteur-Roux, Paris, France & University Paris XI, Orsay, 09/2001-06/2002, Molecular Biology of the Cell
Ph.D., INSERM U550, Necker Medical School, University Paris Descartes, France, 07/2002-12/2006, Genetics, Biochemistry, Cell Biology, Immunology (heads: Jean-Laurent Casanova and Laurent Abel)
Post-Doctoral Fellow, Laboratory of Molecular Mechanisms of Innate Immunity, Weill Medical College of Cornell University, NY, NY, USA, 01/2007-08/2010, Mycobacterium tuberculosis and Human Macrophages (head: Carl Nathan)
Post-Doctoral Associate, St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, NY, NY, USA, 09/2010-09/2011, Whipple’s disease (head: Jean-Laurent Casanova)
Research Associate, INSERM U980, Necker Medical School, University Paris Descartes, France, INSERM (CR2), 10/2011-01/2014, Whipple’s disease (heads: Laurent Abel and Jean-Laurent Casanova)
HDR (Habilitation to supervise research), University Paris Descartes, France, 2013
Research Associate, Human Genetics, INSERM U1163, IMAGINE Institute, 24 bd du Montparnasse, 75015, University Paris Descartes, France, INSERM (CR2), 02/2014-01/2015, Whipple’s disease, Human Behavioral Genetics
Senior Research Associate ,INSERM U1163, IMAGINE Institute, 24 bd du Montparnasse, 75015, University Paris Descartes, France, INSERM (CR1), 01/2015-12/2015, Whipple’s disease, Human Behavioral Genetics
Senior Research Associate, Laboratory of Medical Ethics and Legal Medicine EA4569, Medical School, 45 rue des Saints-Peres, 75006, University Paris Descartes, France, INSERM (CR1), 12/2015-present, Human Behavioral Genetics, Primary Premature Ejaculation, Gender Dysphoria, Neglected Human Genetics
Senior Research Associate, Centre National de Genotypage (CNG), 2, rue Gaston Cremieux, CP-5721, 91057 Evry Cedex, INSERM (CR1), 04-2016-present, Human Behavioral Genetics, Primary Premature Ejaculation, Gender Dysphoria

2013 : Albert Sezary Prize, National Academy of Medicine, Paris France
2008 : Societé française d’Immunologie Young Investigator Award (Ozyme), Paris, France
2007 : Pediatric Pathology Prize, Association for Study of Pediatric Pathology, Paris, France
2006 : Thermo Fisher Scientific Biotherapy Prize (formerly Jouan Prize)
2006 : Spetsai Summer School Advanced Lecture Course, Federation of European Biochemical Societies (FEBS)
2006 : Journées de Biologie Clinique Necker-Pasteur Award, Paris, France
2005 : Societé française d’Immunologie Symposium Award, Toulouse, France
2005 : Symposium Award, Annual Conference of the Society for Glycobiology, Boston, MA, USA
2005 : Necker “Congress of Young Researchers” Symposium Award, Paris, France
2005 : 1st Prize of the French Society of Pediatrics, Pediatrics Symposium, Paris, France

1: Stoeklé HC, Mamzer-Bruneel MF, VOGT G*, Christian Hervé*. 23andMe: a new two-sided data banking market model., (under review)
2: Martinez-Barricarte R*, Megged O*, Stepensky P, Casimir P, Moncada-Velez M, Averbuch D, Assous MV, Abuzaitoun O, Kong XF, Pedergnana V, Deswarte C, Migaud M, Rose-John S, Itan Y, Boisson B, Belkadi A, Conti F, Abel L, VOGT G, Boisson-Dupuis S, Casanova JL*, Bustamante J*. Mycobacterium simiae Infection in Two Unrelated Patients with Different Forms of Inherited IFN-gammaR2 Deficiency. J Clin Immunol. 2014 Nov;34(8):904-909.
3: Moncada-Vélez M, Martinez-Baricarte R, Kong XF, Blancas-Galicia L, Kutukculer N, Ramírez-Alejo N, Okada S, Kreins AY, Bryant VL, Bogunovic D, Franco JL, Espinosa-Padilla S, Yamazaki-Nakashimada M, Espinosa-Rosales F, Abel A, Bustamante J*, VOGT G*, Casanova JL*, Stéphanie Boisson-Dupuis S*. Partial IFN-γR2 deficiency is due to protein misfolding and can be rescued with inhibitors of glycosylation. Blood. 2013 Oct 3;122(14):2390-401
4 : Itan Y, Zhang SY, VOGT G, Abhyankar A, Quintana-Murci L, Abel L, Casanova JL. The Human Genes Connectome: A Map of Short Cuts for Morbid Alleles Discovery. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5558-63
5: Kong XF, VOGT G*, Itan Y*, Macura-Biegun A*, Szaflarska A, Kowalczyk D, Chapgier A, Abhyankar A, Furthner D, Djambas Khayat C, Okada S, Bryant V, Bogunovic D, Kreins A, Moncada Velez M, Migaud M, Al-Ajaji S, Al-Muhsen S, Holland SM, Abel L, Picard C, Chaussabel D, Bustamante J, Casanova JL, and Boisson-Dupuis S. Haploinsufficiency at the human IFNGR2 locus contributes to mycobacterial disease . Hum Mol Genet 2013 Feb 15;22(4):769-781.

Primary Premature Ejaculation, Gender Dysphoria